古丽莎 | 17c呱呱爆料

古丽莎

主任医师博士生导师硕士生导师

导师介绍

【学位 / 学历】

博士 / 博士研究生

【学术简历】

1999.09-2004.06??中山大学口腔医学专业获学士学位

2004.09-2007.06 ?中山大学口腔临床医学专业获硕士学位

2007.09-2010.02 ?中山大学口腔临床医学专业获博士学位

2008.09-2010.06 ?美国佐治亚医学院口腔临床医学专业联合培养博士

（国家留学基金委）

【研究方向】

1.仿生矿化材料与骨组织再生修复

2.牙本质胶原功能化修饰

【主持课题】

1.?2019.01.01-2022.12.31：《蚕颁惭颁牙本质纤维外脱矿的疏水性粘接体系构建及机制研究》，国家自然科学基金面上项目，57万

2.?2019.04 -2022.03：《蚕颁惭颁纤维外脱矿粘接体系提高树脂牙本质粘接耐久性的研究》，广州市科技计划一般项目，20万

3.?2018.05-?2021.04：《基于壳聚糖纤维外脱矿牙本质疏水性粘接模型的构建及机制研究》，广东省自然科学基金项目，10万

4.?2024.01-2026.12：《高分子量笔础础狈的合成及其对牙本质胶原支架结构特征与成骨效应的调控作用》，广东省自然科学基金项目，10万

5.?2025.01-2027.12：《氧化铈纳米酶激活础罢笔13础3介导多胺转运促进肥胖大鼠骨缺损修复的研究》，广东省自然科学基金项目，10万

【发表论文】

1. Chen SS#, Qu Y#, Wang ZR#, Zhang YL, Wang WY, Du RY, Li WC, Gu LS. Cerium oxide nanozymes-driven polyamine metabolic reprogramming for bone regeneration in high-fat environments, Chem Eng J. 2025, 164111.

2. Huang Q#, Qu Y, Tang M, Lan K, Zhang Y, Chen S, Li WC, Gu LS. ROS-responsive hydrogel for bone regeneration: Controlled dimethyl fumarate release to reduce inflammation and enhance osteogenesis. Acta Biomater. 2025 Mar 15:195:183-200. doi: 10.1016/j.actbio.2025.02.026.

3. Chen H#, Li ZH, Yu QQ, Li WC, Gu LS*. Antimicrobial and adhesive dendritic polymer coatings with real-Time in situ monitoring via aggregation-induced emission. Advanced Composites and Hybrid Materials. 2025; 8(2): 211.

4. Wang W#, Qu Y, Chen H, Huang L, Gu LS. The microbial co-infection interaction network in apical periodontitis with sinus tracts. J Dent. 2024 Dec 1;153:105496. doi: 10.1016/j.jdent.2024.105496. Epub ahead of print. PMID: 39626841.

5. Zhang Y#, Chen T, Gu LS, Yuan R, Cao Y, Lin H, Zhi Q. Effect of the stability of the poly(gamma-glutamic acid)-ACP dispersion system on biomimetic mineralization of type I collagen. Biomater Sci. 2024;13(3):795-809.

6. Wang W#, Zeng Q, Li Y, Sun Y, Kim T, Tang J, Bergeron BE, Tay F, Gu LS. Effectiveness of pulpotomy in managing carious exposure in mature permanent teeth: A systematic review and meta-analysis. J Dent. 2024;150.

7. Li Y#, Wang W#, Zeng Q, Tang M, Massey J, Bergeron BE, Gu LS, Tay FR. Efficacy of pulpotomy in managing irreversible pulpitis in mature permanent teeth: A systematic review and meta-analysis. J Dent. 2024;144.

8. Wang ZR#, Zhang YL#, Chen SS#, Qu Y, Tang MC, Wang WY, Li WC, Gu LS. Multifunctional CeO2 nanozymes for mitigating high-glucose induced senescence and enhancing bone regeneration in type 2 diabetes mellitus. Chem Eng J. 2024; 149842.

9. Li ZH#, Huang QX, Wang ZR, Huang LJ, Gu LS*. Effects of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans on Modeling Subgingival Microbiome and Impairment of Oral Epithelial Barrier. J Infect Dis. 2024 Jan 12;229(1):262-272. doi: 10.1093/infdis/jiad461.

10. Qu Y#, Wen YT#, Chen M, Guo KL, Huang XY, Gu LS. Predicting case difficulty in endodontic microsurgery using machine learning algorithms. J Dent. 2023 Jun;133:104522. doi: 10.1016/j.jdent.2023.104522. Epub 2023 Apr 18. PMID: 37080531.

11. Chen S#, Arola D, Ricucci D, Bergeron BE, Branton JA, Gu LS, Tay FR. Biomechanical perspectives on dentine cracks and fractures: Implications in their clinical management. J Dent. 2023 Mar;130:104424. doi: 10.1016/j.jdent.2023.104424. Epub 2023 Jan 16. PMID: 36657703.

12. Shan T#, Huang L, Tay FR, Gu LS. Retention of Intrafibrillar Minerals Improves Resin-Dentin Bond Durability. J Dent Res. 2022;101(12):1490-1498. doi:10.1177/00220345221103137.

13. Qu Y#, Lin Z, Yang Z, Lin H, Huang X, Gu LS. Machine learning models for prognosis prediction in endodontic microsurgery. J Dent. 2022;118:103947. doi:10.1016/j.jdent.2022.103947.

14. Wang LX#, Chen H, Lin RT, Gu LS*. Influence of pecking frequency at working length on the volume of apically extruded debris: A micro-computed tomography analysis. J Dent Sci. 2022;17(3):1274-1280. doi:10.1016/j.jds.2021.11.012.

15. Wang L#, Lin R, Chen H, Li Z, Tay FR, Gu LS. Influence of the Number of Pecking Motions at Working Length on the Shaping Ability of Single-file Systems in Long Oval-shaped Curved Canals. J Endod. 2022;48(4):548-554. doi:10.1016/j.joen.2022.01.009.

16. Lin R#, Wang Z, Li Z, Gu LS*. A two-phase and long-lasting multi-antibacterial coating enables titanium biomaterials to prevent implants-related infections. Mater Today Bio. 2022;15:100330. Published 2022 Jun 16. doi:10.1016/j.mtbio.2022.100330.

17. 林锐钿#,李子涵,古丽莎*.内质网应激在骨代谢及其稳态中的作用[J].中华口腔医学研究杂志(电子版),2021,15(05):309-313.

18. Huang Q#, Huang X, Gu LS*. Periodontal Bifunctional Biomaterials: Progress and Perspectives. Materials (Basel). 2021;14(24):7588. doi:10.3390/ma14247588.

19. Shan TT#, Tay FR, Gu LS*. Application of artificial intelligence in dentistry. J Dent Res. 2021 Mar;100(3):232-244. doi: 10.1177/0022034520969115.

20. Chen H#, Gu LS, Liao B, Zhou X, Cheng L, Ren B. Advances of Anti-Caries Nanomaterials. Molecules. 2020;25(21):5047.

21. Shan TT#, Qu Y, Huang XY, Gu LS*. Cone-beam computed tomography analysis of accessary canals of the canalis sinuosus: a prevalent but often overlooked anatomical variation in the anterior maxilla. J Prosthet Dent, 2020 Sep 28:S0022-3913(20)30435-2. doi: 10.1016/j.prosdent.2020.05.028.

22. Zhao MD#, Qu Y, Liu J, Mai S, Gu LS. A universal adhesive incorporating antimicrobial peptide nisin: effects on Streptococcus mutans and saliva?derived multispecies biofilms. Odontology, 2020 Jul;108(3):376-385.

23. Zhao MD#, Shan TT, Wu Q, Gu LS*. The antibacterial effect of graphene oxide on streptococcus mutans. J Nanosci Nanotechnol. 2020 Apr 1;20(4):2095-2103.

24. 古丽莎#，龚启梅，周玉竹，韦曦*. 新型冠状病毒肺炎疫情期间对急性牙痛临床诊疗工作的防控建议.中华口腔医学研究杂志（电子版），2020,14(1): 9-13.

25. 古丽莎#,韦曦,凌均棨*. 氟牙症的病因、诊断与防治.?中华口腔医学杂志，2020,55(5)：296-301.

【参编教材与论着】

1.?2020年参编《牙体牙髓病病例精解》科学技术文献出版社 2020 9787518961115

2.?2024年参编《牙体牙髓病多学科诊疗病例精粹》人民卫生出版社

9787117359917

3.?2024年参编《牙体牙髓病临床治疗新技术》科学技术文献出版社 ?9787523507155

【获奖及学术荣誉】

1.?2020年 17c呱呱爆料优秀教师奖二等奖

2.?2021、2025年 17c呱呱爆料优秀共产党员

3.?2021年 17c呱呱爆料临床病例竞赛二等奖

4.?2021年 17c呱呱爆料优秀教师奖二等奖

5.?2021、2022、2023年光华口腔医学院光华园丁奖叁等奖

6.?2022年第四届广东省医院协会医院管理创新奖二等奖

7.?2023年入选贰濒蝉别惫颈别谤“全球前2%顶尖科学家榜单”

8.?2023年广东省第二届健康科普大赛视频类叁等奖

9.?2023年中山大学第十一届校级本科教育教学奖二等奖

10.?2024年中华口腔医学会科技奖一等奖

11.?2024年广东省医院协会“医院管理与科技创新奖”一等奖

12.?2024年 17c呱呱爆料光华园丁奖一等奖

13.?2024年第十届全国大学生基础医学创新研究暨实验设计论坛总决赛“优秀指导教师”

【社会兼职】

1.?中华口腔医学会第七届牙体牙髓病学专业委员会委员

2.?中华口腔医学会第八届牙体牙髓病学专业委员会委员

3.?广东省口腔医学会第四届牙体牙髓病学专业委员会常务委员

4.?Journal of Dentistry编委

【联系方式】

地址：广州市越秀区陵园西路56号17c呱呱爆料

电话：020-83861544

邮箱：驳耻濒颈蝉丑补蔼尘补颈濒.蝉测蝉耻.别诲耻.肠苍

17c呱呱爆料

【研究方向】

1.仿生矿化材料与骨组织再生修复

2.牙本质胶原功能化修饰

【主持课题】

【发表论文】

1. Chen SS#, Qu Y#, Wang ZR#, Zhang YL, Wang WY, Du RY, Li WC*, Gu LS*. Cerium oxide nanozymes-driven polyamine metabolic reprogramming for bone regeneration in high-fat environments, Chem Eng J. 2025, 164111.

2. Huang Q#, Qu Y, Tang M, Lan K, Zhang Y, Chen S, Li WC*, Gu LS*. ROS-responsive hydrogel for bone regeneration: Controlled dimethyl fumarate release to reduce inflammation and enhance osteogenesis. Acta Biomater. 2025 Mar 15:195:183-200. doi: 10.1016/j.actbio.2025.02.026.

3. Chen H#, Li ZH, Yu QQ*, Li WC*, Gu LS*. Antimicrobial and adhesive dendritic polymer coatings with real-Time in situ monitoring via aggregation-induced emission. Advanced Composites and Hybrid Materials. 2025; 8(2): 211.

4. Wang W#, Qu Y, Chen H, Huang L*, Gu LS*. The microbial co-infection interaction network in apical periodontitis with sinus tracts. J Dent. 2024 Dec 1;153:105496. doi: 10.1016/j.jdent.2024.105496. Epub ahead of print. PMID: 39626841.

5. Zhang Y#, Chen T, Gu LS, Yuan R, Cao Y, Lin H*, Zhi Q*. Effect of the stability of the poly(gamma-glutamic acid)-ACP dispersion system on biomimetic mineralization of type I collagen. Biomater Sci. 2024;13(3):795-809.

6. Wang W#, Zeng Q, Li Y, Sun Y, Kim T, Tang J, Bergeron BE, Tay F*, Gu LS*. Effectiveness of pulpotomy in managing carious exposure in mature permanent teeth: A systematic review and meta-analysis. J Dent. 2024;150.

7. Li Y#, Wang W#, Zeng Q, Tang M, Massey J, Bergeron BE, Gu LS*, Tay FR*. Efficacy of pulpotomy in managing irreversible pulpitis in mature permanent teeth: A systematic review and meta-analysis. J Dent. 2024;144.

8. Wang ZR#, Zhang YL#, Chen SS#, Qu Y, Tang MC, Wang WY, Li WC*, Gu LS*. Multifunctional CeO2 nanozymes for mitigating high-glucose induced senescence and enhancing bone regeneration in type 2 diabetes mellitus. Chem Eng J. 2024; 149842.