范文国
副教授
主任医师
博士生导师
硕士生导师
导师介绍
【学位 / 学历】
博士 / 博士研究生
【学术简历】
1996.09-2000.06 青岛大学临床医学专业
2003.09-2006.06 青岛大学人体解剖与组织胚胎学/神经生物学专业获硕士学位
2006.09-2009.06 中山大学人体解剖与组织胚胎学/神经生物学获博士学位
2009.07-2012.12 中山大学光华口腔医学院/附属口腔医院麻醉科主治医师/讲师
2013.01-2016.06 中山大学光华口腔医学院/附属口腔医院麻醉科副主任医师/副教授 硕士生导师
2016.07-2023.12 中山大学光华口腔医学院/附属口腔医院麻醉科副主任医师/副教授 博士生导师
2024.01-至今 中山大学光华口腔医学院/附属口腔医院麻醉科主任医师/副教授 博士生导师
【研究方向】
1. 口颌面疼痛调控机制
2. 口颌面疼痛神经免疫机制
【主持课题】
2022年：《卫星胶质细胞础搁介导交感效应调控巨噬细胞表型参与口
颌面疼痛的外周机制》，国家自然科学基金，50万
【发表论文】
1. Fan, W.;Mai, L.;Zhu, X.;Huang, F.;He, H. The Role of Microglia in Perioperative Neurocognitive Disorders. Front Cell Neurosci. 2020; 14,261
2. Gao, X.;Qin, W.;Chen, L.;Fan, W.;Ma, T.;Schneider, A.;Yang, M.;Obianom, O.N.;Chen, J.;Weir, M.D. Effects of Targeted Delivery of Metformin and Dental Pulp Stem Cells on Osteogenesis via Demineralized Dentin Matrix under High Glucose Conditions. ACS Biomater Sci Eng. 2020; 6,2346-2356
3. Jiang, L.;Zhang, F.;Fan, W.;Zheng, M.;Kang, J.;Huang, F.;He, H. Expression of circadian clock genes during differentiation of rat dental papilla cells in vitro. Biological Rhythm Research. 2020;53, 753-764
4. Li, H.;Fan, W.;Zhu, X. Three-dimensional printing: The potential technology widely used in medical fields. J Biomed Mater Res A. 2020; 108,2217-2229
5. Li, J.;Deng, Q.;Fan, W.;Zeng, Q.;He, H.;Huang, F. Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells. Bioengineered. 2020; 11,829-840
6. Liang, G.;Fan, W.;Luo, H.;Zhu, X. The emerging roles of artificial intelligence in cancer drug development and precision therapy. Biomed Pharmacother. 2020; 128,110255
7. Mai, L.;Huang, F.;Zhu, X.;He, H.;Fan, W. Role of Nerve Growth Factor in Orofacial Pain. J Pain Res. 2020; 13,1875-1882
8. Mai, L.;Zhu, X.;Huang, F.;He, H.;Fan, W. p38 mitogen-activated protein kinase and pain. Life Sci. 2020; 256,117885
9. Xie, S.;Fan, W.;He, H.;Huang, F. Role of Melatonin in the Regulation of Pain. J Pain Res. 2020; 13,331-343
10. Xie, S.S.;Fan, W.G.;Liu, Q.;Li, J.Z.;Zheng, M.M.;He, H.W.;Huang, F. Involvement of nNOS in the antinociceptive activity of melatonin in inflammatory pain at the level of sensory neurons. Eur Rev Med Pharmacol Sci. 2020; 24,7399-7411
11. Zheng, M.;Zhang, F.;Fan, W.;Jiang, L.;Li, J.;Xie, S.;Huang, F.;He, H. Suppression of osteogenic differentiation and mitochondrial function change in human periodontal ligament stem cells by melatonin at physiological levels. PeerJ. 2020; 8,e8663
12. Zhou, Y.;Kong, Y.;Fan, W.;Tao, T.;Xiao, Q.;Li, N.;Zhu, X. Principles of RNA methylation and their implications for biology and medicine. Biomed Pharmacother. 2020; 131,110731
13. Zhu, X.;Li, H.;Huang, L.;Zhang, M.;Fan, W.*;Cui, L. 3D printing promotes the development of drugs. Biomed Pharmacother. 2020; 131,110644
14. Chen, H.;Kang, J.;Zhang, F.;Yan, T.;Fan, W.;He, H.;Huang, F. SIRT4 regulates rat dental papilla cell differentiation by promoting mitochondrial functions. Int J Biochem Cell Biol. 2021; 134,105962
15. Kang, J.;Chen, H.;Zhang, F.;Yan, T.;Fan, W.;Jiang, L.;He, H.;Huang, F. RORalpha Regulates Odontoblastic Differentiation and Mediates the Pro-Odontogenic Effect of Melatonin on Dental Papilla Cells. Molecules. 2021; 26, 1098.
16. Liu, Q.;Fan, W.;He, H.;Huang, F. The role of peripheral opioid receptors in orofacial pain. Oral Dis. 2021; 27,1106-1114
17. Liu, Q.;He, H.;Mai, L.;Yang, S.;Fan, W.;Huang, F. Peripherally Acting Opioids in Orofacial Pain. Front Neurosci. 2021; 15,665445
18. Ma, H.;Kang, J.;Fan, W.;He, H.;Huang, F. ROR: Nuclear Receptor for Melatonin or Not? Molecules. 2021; 26, 2693.
19. Mai, L.;Liu, Q.;Huang, F.;He, H.;Fan, W. Involvement of Mast Cells in the Pathophysiology of Pain. Front Cell Neurosci. 2021; 15,665066
20. Yan, T.;Kong, Y.;Fan, W.;Kang, J.;Chen, H.;He, H.;Huang, F. Expression of nitric oxide synthases in rat odontoblasts and the role of nitric oxide in odontoblastic differentiation of rat dental papilla cells. Dev Growth Differ. 2021; 63,354-371
21. Yang, S.;Fan, W.;Li, Y.;Liu, Q.;He, H.;Huang, F. Autophagy in tooth: Physiology, disease and therapeutic implication. Cell Biochem Funct. 2021; 39,702-712
22. Chen, H.;Fan, W.;He, H.;Huang, F. PGC-1: a key regulator in bone homeostasis. J Bone Miner Metab. 2022; 40,1-8
23. Chu, Y.;He, H.;Liu, Q.;Jia, S.;Fan, W.;Huang, F. The Circadian Clocks, Oscillations of Pain-Related Mediators, and Pain. Cell Mol Neurobiol. 2023; 43,511-523.
24. Jia, S.;Liu, J.;Chu, Y.;Liu, Q.;Mai, L.;Fan, W. Single-cell RNA sequencing reveals distinct transcriptional features of the purinergic signaling in mouse trigeminal ganglion. Front Mol Neurosci. 2022; 15,1038539
25. Liu, J.;Jia, S.;Huang, F.;He, H.;Fan, W. Peripheral role of glutamate in orofacial pain. Front Neurosci. 2022; 16,929136
26. Liu, Q.;Mai, L.;Yang, S.;Jia, S.;Chu, Y.;He, H.;Fan, W*.;Huang, F. Transcriptional Alterations of Mouse Trigeminal Ganglion Neurons Following Orofacial Inflammation Revealed by Single-Cell Analysis. Front Cell Neurosci. 2022; 16,885569
27. Ma, H.;Chen, W.;Fan, W.;He, H.;Huang, F. Roles of LonP1 in Oral-Maxillofacial Developmental Defects and Tumors: A Novel Insight. Int J Mol Sci. 2022; 23, 13370.
28. Mai, L.;Jia, S.;Liu, Q.;Chu, Y.;Liu, J.;Yang, S.;Huang, F.;Fan, W. Sympathectomy Ameliorates CFA-Induced Mechanical Allodynia via Modulating Phenotype of Macrophages in Sensory Ganglion in Mice. J Inflamm Res. 2022; 15,6263-6274
29. Xu, K.;Chu, Y.;Liu, Q.;Fan, W.;He, H.;Huang, F. NEDD4 E3 Ligases: Functions and Mechanisms in Bone and Tooth. Int J Mol Sci. 2022; 23,
30. Yang, S.;Liu, Q.;Chen, S.;Zhang, F.;Li, Y.;Fan, W.;Mai, L.;He, H.;Huang, F. Extracellular vesicles delivering nuclear factor I/C for hard tissue engineering: Treatment of apical periodontitis and dentin regeneration. J Tissue Eng. 2022; 13,20417314221084095
31. Chu, Y.;He, H.;Liu, Q.;Jia, S.;Fan, W.;Huang, F. The Circadian Clocks, Oscillations of Pain-Related Mediators, and Pain. Cell Mol Neurobiol. 2023; 43,511-523
32. Chu, Y.;Jia, S.;Xu, K.;Liu, Q.;Mai, L.;Liu, J.;Fan, W*.;Huang, F. Single-cell transcriptomic profile of satellite glial cells in trigeminal ganglion. Front Mol Neurosci. 2023; 16,1117065
33. Chu, Y.;Wu, Y.;Jia, S.;Xu, K.;Liu, J.;Mai, L.;Fan, W.*;Huang, F. Single-nucleus transcriptome analysis reveals transcriptional profiles of circadian clock and pain related genes in human and mouse trigeminal ganglion. Front Neurosci. 2023; 17,1176654
34. Jia, S.;Mai, L.;Yang, H.;Huang, F.;He, H.;Fan, W. Cross-species gene expression patterns of purinergic signaling in the human and mouse trigeminal ganglion. Life Sci. 2023; 332,122130
35. Jia, S.;Yang, H.;Huang, F.;Fan, W. Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders. Inflamm Res. 2023; 72,1895-1907
36. Yang, S.;Huang, F.;Zhang, F.;Sheng, X.;Fan, W.;Dissanayaka, W.L. Emerging Roles of YAP/TAZ in Tooth and Surrounding: from Development to Regeneration. Stem Cell Rev Rep. 2023; 19,1659-1675
37. Zhang, F.;Yang, S.;Jiang, L.;Liu, J.;He, Y.;Sheng, X.;Chen, H.;Kang, J.;Jia, S.;Fan, W.*; He, H. Melatonin-mediated malic enzyme 2 orchestrates mitochondrial fusion and respiratory functions to promote odontoblastic differentiation during tooth development. J Pineal Res. 2023; 74,e12865
38. Hua, X.;Chen, Y.;Wu, Z.;Zheng, G.;Yang, D.;Li, J.;Wu, Q.;Fan, W. Effects of intra-operative magnesium sulfate infusion on orthognathic surgery: A prospective and randomized controlled trial. Heliyon. 2024; 10,e30342
39. Zou, Z.;Fan, W.;Liu, H.;Liu, Q.;He, H.;Huang, F. The roles of 5-HT in orofacial pain. Oral Dis. 2024;30,3838-3849.
【参编教材与论着】
1.?2025年?参编《口腔解剖生理学》 人民卫生出版社 第九版
2.?2024年?参编《口腔癌、口咽癌—全生命周期诊疗与康复》 人民卫生出版社 978-7-117-37098-1
3.?2020年?参编《中国医学教育题库（口腔医学）口腔解剖生理学》 人民卫生出版社 978-7-89456-793-2
4.?2020 参编《实验口腔颌面解剖学》 中山大学出版社 978-7-306-06826-2
【社会兼职】
1.?广东省口腔医学会口腔镇静镇痛专业委员会副主任委员
2.?中华口腔医学会口腔急诊专业委员会委员
3.?中华口腔医学会口腔麻醉专业委员会委员
4.?广东省医师协会麻醉科医师分会委员
【联系方式】
地址：广州市陵园西路56号中山大学光华口腔医学院·附属口腔医院（510055）
电话：020-83871483
邮箱：蹿补苍飞别苍驳蔼尘补颈濒.蝉测蝉耻.别诲耻.肠苍
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