徐琼
教授
主任医师
博士生导师
硕士生导师
导师介绍
【学位 / 学历】
博士 / 博士研究生
【学术简历】
1988-1993 ?武汉大学口腔医学专业获学士学位
1993-1996??武汉大学生物化学专业获硕士学位
2000-2003??武汉大学口腔临床医学专业获博士学位
【研究方向】
1. 牙髓根尖周病的致病机制
2. 牙髓细胞分化的表观遗传调控机制
3. 牙髓根尖周病疑难病例的临床诊治
【主持课题】
1.?2023年：《狈础罢10调控牙髓炎中巨噬细胞贬滨贵-1α/乳酸轴影响牙髓干细胞分化的机制研究》，国家自然科学基金面上项目48万
2.?2024年：《N-乙酰转移酶NAT10通过Nox2-ROS- NF-κB通路调控巨噬细胞糖代谢重编程的机制研究》，广东省自然科学基金面上项目，15万
3.?2022年：《m6础甲基转移酶惭贰罢罢尝3通过笔骋颁1β介导的线粒体能量代谢促进破骨细胞分化的分子机制》，广东省自然科学基金面上项目，10万
4.?2017年：《顿狈础甲基化对尝笔厂诱导牙髓细胞炎症反应的影响及调控机制》，国家自然科学基金面上项目，57万
【发表论文】
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1. Zhan DJ,?Wang F,?Zeng DL,?Hao LL,?Ye Li,?Qi YP*?,?Xu Q*. Development of a radiomic model to detect the retromolar canal on panoramic radiographs. Discov Med, 2025，37(193):383-393.
2. He JL#,?Zhao YQ#,?Zhang YW,?Zhang ZQ,?Li D*, Xu Q*. FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions. Cell Signal, 2024, 117:111098
3. Zhang WJ#,?Bai YJ#,?Hao LL#,?Zhao YQ,?Zhang LJ,?Ding WQ,?Qi YP,?Xu Q*. One-carbon metabolism supports s-adenosylmethionine and m6A methylation to control the osteogenesis of BMSCs and bone formation. J Bone Miner Res, 2024，39(9): 1356-1370??
4. Bai YJ#, Zhang WJ#, Hao LL#, Zhao YQ, Tsai I-Chen, Qi YP,* Xu Q*. Acetyl-CoA-dependent ac4C acetylation promotes the osteogenic differentiation of LPS-stimulated BMSCs. Int Immunopharmacol,?2024,133:112124
5. Zhang LJ#,?Tsai I-Chen#?,?Ni ZH,?Chen BC,?Zhang?SY,?Cai LH,?Xu Q*. Copper chelation therapy attenuates periodontitis inflammation through cuproptosis/ autophagy/lysosome axis. Int J Mol Sci, 2024, 25(11):5890
6. Zhao YQ#,?Ding WQ#,?Cai YJ,?Li QM,?Zhang WJ,?Bai YJ,?Zhang YW,?Xu Q*,?Feng ZH*. The m6A eraser FTO suppresses ferroptosis via mediating ACSL4 in LPS-induced macrophage inflammation. Biochim Biophys Acta Mol Basis Dis, 2024, 1870(7):167354
7. Zhang YW#, Kong YP#, Zhang WJ#, He JL, Zhang ZQ, Cai YJ, Zhao YQ，Xu Q*. METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis. Clin Epigenetics,?2024,16(1):18.
8. Zhang ZQ, Zhang YW, Cai YJ, Li D, He JL, Feng ZH*, Xu Q*. NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF-κB pathway in macrophages. Biochim Biophys Acta Mol Cell Res,?2023,1870(7):119521.
9. Cai YJ#, Yu RQ#, Zhang ZQ, Li D, Yi BC, Feng ZH,* Xu Q*. Mettl3/Ythdf2 regulate macrophage inflammation and ROS generation by controlling Pyk2 mRNA stability. Immunology Letters, 2023, 264 (2023): 64-73
10. Li D#, He JL#, Fang CH, Zhang YW, He ML, Zhang ZQ, Hou JS*, Xu Q*. METTL3 regulates osteoclast biological behaviors via iNOS/NO-Mediated mitochondrial dysfunction in inflammatory conditions. Int J Mol Sci,?2023, 24(2):1403.
11. He ML#, Li D#, Fang CH, Xu Q*. YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis. Arch Biochem Biophys, 2022, 732:109464
12. Cai LH, Li D, Feng ZH, Gu XF,?Xu Q*, Li Q*. YTHDF2 regulates macrophage polarization through NF-κB and_MAPK signaling pathway inhibition or p53 degradation. Dis Markers, 2022:3153362
13. Yang Y,?Lin Y,?Xu R,?Zhang Z,?Zeng W,?Xu Q*,?Deng F*. Micro/Nanostructured Topography on Titanium Orchestrates Dendritic Cell Adhesion and Activation via β2 Integrin-FAK Signals. Int J Nanomedicine,?2022,1;17: 5117-5136.
14. Cai Y#, Yu R#,?Kong Y,?Feng Z,?Xu Q*. METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway. Cell Signal, 2022;93:110283.
15. Kong Y#,?Zhang Y#, Cai Y, Li D, Yi B, Xu Q*. METTL3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during LPS-induced inflammation. Cell Signal, 2022; 95:110335.
16. Fang C#, He M#, Li D, Xu Q*. YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways. Cell Signal,?2021, 85: 110060.
17. Feng Z#, Meng R #, Li Q, Li D, Xu Q*. 5-aza-2’-deoxycytidine may regulate the inflammatory response of human odontoblast-like cells through the NF-κB pathway. Int Endod J, 2021;54(7):1105-1117
18. Pang L, Li X, Wang K, Tao Y, Cui T, Xu Q*, Lin H *. Interactions with the aquaporin 5 gene increase the susceptibility to molar-incisor hypomineralization. Arch Oral Biol, 2020;111:104637.
19. Li Q#, Li J#, Feng Z, Lin H *, Xu Q*. Effect of histone demethylase KDM5A on the odontogenic differentiation of human dental pulp cells. Bioengineered,2020,11(1):449-462
20. Li D#, Cai L#, Meng R, Feng Z, Xu Q*. METTL3 modulates osteoclast differentiation and function by controlling RNA stability and nuclear export. Int J Mol Sci, 2020, 21(5): 1660.
21. Gu X#,?Zhang Y#,?Li D,?Cai H,?Cai L,?Xu Q*. N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation. Cell Signal,?2020, 69:109553.
22. Zhang Y#, Gu X#, Li D, Cai L, Xu Q*. METTL3 regulates osteoblast differentiation and inflammatory response via Smad signaling and MAPK signaling. Int J Mol Sci,?2020, 21(1): E119
23. Cai L#, Zhan M#, Li Q，Li D, Xu Q*. DNA methyltransferase DNMT1?inhibits?lipopolysaccharideinduced?inflammatory?response?in?human?dental pulp?cells?involving?the?methylation?changes?of IL6 and?TRAF6. Mol Med Rep,?2020, 21(2): 959-968.
【参编教材与论着】
1.?2020年：参编《牙体牙髓病学病例精解》?科学技术文献出版社?
2.?2024年：参编《牙体牙髓病多学科诊疗病例精粹》?人民卫生出版社 9787117359917
【社会兼职】
1.?中华口腔医学会牙体牙髓病学专业委员会常委
2.?广东省口腔医学会牙体牙髓病学专业委员会常委
【联系方式】
地址：广州市陵园西路56号中山大学光华口腔医学院附属口腔医院
邮箱：xuqionggz@sina.cn ??xqiong@mail.sysu.edu.cn
