王彦
研究员
博士生导师
硕士生导师
导师介绍
【学位 / 学历】
博士 / 博士研究生
【学术简历】
1878-1983 佳木斯大学口腔医学专业获学士学位
1985-1988 白求恩医科大学口腔临床医学专业硕士学位
1993-1996 ?日本大阪大学口腔临床医学专业国家公派访问学者
1996-2000 日本德岛大学齿学部口腔正畸学专业获博士学位
2000-2005 美国宾夕法尼亚大学肿瘤病毒学博士后
【研究方向】
1.间充质干细胞衰老机制的研究
2.间充质干细胞及其胞外囊泡在组织再生与疾病治疗中的应用
3人类肿瘤病毒（碍厂贬痴、贰叠痴）的致瘤分子机制
【主持课题】
1.2016-2021年：《碍厂贬痴持续性感染口腔间充质干细胞与相关肿瘤发生的机制研究》，国自然重点（负责完成课题），327.6万
2.2021.01.01-2024.12.31：《牙周膜干细胞外泌体尘颈搁-92补-3辫通过惭蹿苍1/搁翱厂/贬滨贵1α/尝顿贬础通路调节巨噬细胞代谢和破骨分化》，国家自然科学基金、面上项目，55万
3.2023.01.01-2026.12.31：《牙周膜干细胞线粒体移植通过罢翱叠2/厂惭础顿5/笔碍惭2赋能通路调控牙周骨稳态的机制研究》，国家自然科学基金、面上项目，52万
【发表论文】
1.?Yingying Peng, Tingting Zhao, Shuxuan Rong, Shuqing Yang ,Wei Teng*,Yunyi Xie* and Yan Wang*. Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics. Journal of ?Nanobiotechnology.2024;22(1):543
2.?Niu Q#, Lin C#, Yang S, Rong S, Wei J, Zhao T, Peng Y, Cheng Z, Xie Y*, Wang Y*. FoxO1-Overexpressed Small Extracellular Vesicles Derived from hPDLSCs Promote Periodontal Tissue Regeneration by Reducing Mitochondrial Dysfunction to Regulate Osteogenesis and Inflammation. Int J Nanomedicine.International Journal of Nanomedicine 2024;19:8751-8768
3.?Lu ZZ, Sun C, Zhang X, Peng Y, Wang Y, Zeng Y, Zhu N, Yuan Y, Zeng MS. Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated?macropinocytosis.Sci?Adv2023;9(21):eadg1778.
4.?Qingru Niu#，Huan Chen#, Qianmin Ou, Shuqing Yang, Yingying Peng, Yunyi Xie, Le Yu, Zhilan Cheng, Yang Cao*, Yan Wang*. Klotho enhances bone regenerative function of hPDLSCs via modulating immunoregulatory function and cell autophagy. J Orthop Surg Res. 2023;18(1):400
5.?Yunyi Xie#, Le Yu#, Zhilan Cheng#, Yingying Peng, Zeyuan Cao, Beichen Chen, Yihong Duan, Yan Wang*. SHED-derived exosomes promote LPS-induced wound healing with less itching by stimulating macrophage autophagy. Journal of Nanobiotechnology. 2022;20(1):239.
6.?Nannan Zhu, Qian Wang, Zhidong Wu, Yan Wang, Mu-Sheng Zeng, and Yan Yuan .EBV LMP1-activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Properties. J Virol. 2022;96(5):e0194121.
7.?Qianmin Ou#, Shaohan Zhang#, Chuanqiang Fu, Le Yu, Peikun Xin, Zhipeng Gu,Zeyuan Cao, Jun Wu*, Yan Wang*. More natural more better: triple natural anti.oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing. Journal of Nanobiotechnology. 2021;19(1):237.
8.?Lingping Tan#, Zeyuan Cao#, Huan Chen, Yunyi Xie, Le Yu, Chuanqiang Fu, Wei Zhao* and Yan Wang*. Curcumin reduces apoptosis and promotes osteogenesis of human periodontal ligament stem cells under oxidative stress in vitro and in vivo. Life Sciences.?2021;270 :119125.
9.?Jiayuan Hu, Yan Wang, Yan Yuan. Inhibitors of APE1 redox function effectively inhibit γ-herpesvirusreplication in vitro and in vivo. Antiviral Research. 2021;185:104985.
10.?Nannan Zhu, Xiaoting Xu, Yan Wang, Mu-Sheng Zeng, Yan Yun. EBV latent membrane proteins promote hybrid epithelial-mesenchymal and extreme mesenchymal states of nasopharyngeal carcinoma cells for tumorigenicity. PLOS Pathogens.2021;17(8):e1009873.
11.?Yao Ding,?Weikang Chen, Zhengzhou?Lu,Yan Wang, Yan?Yuan.Kaposi's Sarcoma-associated Herpesvirus Promotes Mesenchymal-to-Endothelial Transition by Resolving the Bivalent Chromatin of PROX1 Gene. PLOS Pathogens, PLoS Pathog. 2021;17(9):e1009847.
12.?Weikang Chen,Yao Ding, Zhengzhou Lu, Yan Wang, Yan Yun. Kaposi’s sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis.PLoS Pathog. 2021;17(12): e1009600.
13.?Zeyuan Cao#, Yunyi Xie#, Le Yu, Yi Li, and Yan Wang*. Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways. Stem Cell Research & Therapy?2020;11(1):329.
14.?Qianmin Ou#, Keqing Huang#, Chuanqiang Fu, Chunlin Huang , Yifei Fang, Zhipeng Gu*, Jun Wu, Yan Wang*. Nanosilver-incorporated halloysite nanotubes/gelatin methacrylate hybrid hydrogel with osteoimmunomodulatory and antibacterial activity for bone regeneration. Chemical Engineering Journal, 2020;382:123019.
15.?Huan Chen#, Xiaojun Huang#, Chuanqiang Fu, Xiayi Wu, Yingying Peng, Xuefeng Lin*, and Yan Wang*. Recombinant Klotho protects human periodontal ligament stem cells by regulating mitochondrial function and the antioxidant system during H2O2-induced oxidative stress. Oxidative Medicine and Cellular Longevity. 2019;9261565.
16.?Xiaojun Huang#, Huan Chen#, Yunyi Xie , Zeyuan Cao, Xuefeng Lin* and Yan Wang*. FoxO1 Overexpression Ameliorates TNF-α-Induced Oxidative Damage and Promotes Osteogenesis of Human Periodontal Ligament Stem Cells via Antioxidant Defense Activation, Stem cells international. 2019;2120453.
17.?Yunyi Xie#, Enbao He#, Zeyuan Cao, Qianmin Ou, Yan Wang*. Effect of polyvinylphosphonic acid on resin-dentin bonds and cytotoxicity of MDPC-23. Journal of Prosthetic Dentistry. 2019 ;122(5):492.e1-492.e6.
18.?Suya Chen , Qianmin Ou, Yan Wang*, Xuefeng Lin*. Short Implants (5-8 mm) Versus Long Implants (≥10 mm) with Augmentation in Atrophic Posterior Jaws: A Meta-Analysis of Randomized Controlled Trials. Journal of oral rehabilitation. 2019; 46 (12), 1192-1203.
19.?Suya Chen#, Qianmin Ou#, Xuefeng Lin*, Yan Wang*.Comparison between a computer-aided surgical template and the free-hand method: A systematic review and meta-analysis. Implant Dentistry. 2019;28 (6), 578-589.
20.?Qianmin Ou#, Yingling Miao#, Fanqiao Yang, Xuefeng Lin, Li-Ming Zhang * and Yan Wang *.Zein/gelatin/nanohydroxyapatite nanofibrous scaffolds are biocompatible and promote osteogenic differentiation of human periodontal ligament stem cells. Biomaterials Science, 2019;7(5):1973-1983.
21.?Siqi Yao#, Lingping Tan#, ?Huan Chen, Xiaojun Huang, Wei Zhao*, and Yan Wang*.Potential Research Tool Of Stem Cells From Human Exfoliated Deciduous Teeth: Lentiviral Bmi-1 Immortalization With EGFP Marker. Stem Cells International, 2019;3526409.
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【社会兼职】
《中华口腔医学（电子版）》杂志特邀编委
【联系方式】
地址：广州市越秀区中山二路74号中山大学口腔医学研究所
电话：020-87330592
邮箱：飞补苍驳93蔼尘补颈濒.蝉测蝉耻.别诲耻.肠苍
