范招纳
副主任医师 硕士生导师
导师介绍

【学位 / 学历】

博士?/ 博士研究生

【学术简历】

2005.09-2012.06?山东大学口腔医学（七年制）专业获学士、硕士学位

2015.08-2018.06?中山大学口腔临床医学专业获博士学位

【研究方向】

1.口腔癌的防治

2.口腔潜在恶性疾患的防治

3.疾病诊断标志物的开发

【主持课题】

2021年：《颁颈谤肠-笔搁惭罢5在口腔鳞癌患者唾液中的诊断价值及潜在作用机制研究》，国家自然科学基金青年项目，30万

【发表论文】

1. Jiang S, Ou L, Wang Y, Su K, Chen Z, He L, Xu X, Cheng B, Xia J*, Fan Z*. CircPRMT5, a Potential Salivary Biomarker, Facilitates the Progression of Head and Neck Squamous Cell Carcinoma via the IGF2BP3-SERPINE1 Pathway.?Int J Nanomedicine. 2025 ;20: 1597-1613.

2. Fan Z#, He L#, Li M#, Cao R, Deng M, Ping F, Liang X, He Y, Wu T, Tao X, Xu J, Cheng B*, Xia J*. Targeting methyltransferase PRMT5 retards the carcinogenesis and metastasis of HNSCC via epigenetically inhibiting Twist1 transcription. Neoplasia 2020, 22(11): 617-629.

3. He Y#, Fan Z#, He L, Zhang C, Ping F, Deng M, Liu S, Wang Y, Cheng B*, Xia J*. Metformin Combined with 4SC-202 Inhibited the Migration and Invasion of OSCC via STAT3/TWIST1. OncoTargets and therapy 2020, 13: 11019-11029.

4. Yang Z, Deng M, Ren L, Fan Z, Yang S, Liu S, Ren X, Gao J, Cheng B, Xia J. Pyroptosis of oral keratinocyte contributes to energy metabolic reprogramming of T cells in oral lichen planus via OPA1-mediated mitochondrial fusion. Cell Death Discov. 2024 Sep 17;10(1):408.

5. Wu R, Chen Z, Yu J, Lai P, Chen X, Han A, Xu M, Fan Z, Cheng B, Jiang Y, Xia J. A graph-learning based model for automatic diagnosis of Sj?gren's syndrome on digital pathological images: a multicentre cohort study. J Transl Med. 2024 Aug 8;22(1):748.

6. Xu X, Pan X, Fan Z, Xia J, Ren X. Lactate dehydrogenase B as a metabolism-related marker for immunotherapy in head and neck squamous cell carcinoma. Cell Signal. 2024 Aug; 120: 111200.

7. Deng M, Guo J, Ling Z, Zhang C, He L, Fan Z, Cheng B, Xia J. KRAS mutations upregulate Runx1 to promote occurrence of head and neck squamous cell carcinoma. Mol Carcinog. 2023 Sep;62(9):1284-1294. doi: 10.1002/mc.23563. Epub 2023 May 24.

8. He L, Guo J, Fan Z, Yang S, Zhang C, Cheng B, Xia J. Exosomal miR-146b-5p derived from cancer-associated fibroblasts promotes progression of oral squamous cell carcinoma by downregulating HIPK3. Cell Signal. 2023 Jun; 106: 110635.

9. Zhang C, Wang H, Deng M, He L, Ping F, He Y, Fan Z, Cheng B, Xia J. Upregulated miR4115p levels promote lymph node metastasis by targeting RYBP in head and neck squamous cell carcinoma. Int J Mol Med. 2021 Apr;47(4):36.

【社会兼职】

广东省口腔医学会第二届镇静镇痛专业委员会委员

【联系方式】

地址：广东省广州市天河区东圃大马路3号17c呱呱爆料东圃门诊。

邮箱：蹿补苍锄丑苍3蔼尘补颈濒.蝉测蝉耻.别诲耻.肠苍