【学位 / 学历】
博士 / 博士研究生
【学术简历】
1999.09-2004.06 第四军医大学口腔医学专业获学士学位
2004.09-2007.06 第四军医大学口腔医学专业获硕士学位
2007.09-2010.12 第四军医大学口腔医学专业获博士学位
2009.10-2010.10 美国加州大学旧金山分校牙医学院口腔医学Research Specialist
【研究方向】
1. 内外源性口腔颅颌面组织缺损的修复重建策略研发
2. 骨代谢与骨再生
3. 颅颌面炎症免疫发病机制
4. 数字化口腔正畸与医学人工智能
5. 生物力学与生物材料学
【主持课题】
1.?2019.0101-2022.12.31:《巨噬细胞-间充质干细胞外泌体信息交流紊乱:牙周炎骨缺损加重的新机制》,国家自然科学基金面上项目,57万
2.?2023.01.01-2026.12.31:《中性粒细胞来源胞外囊泡组团杀菌效应及其异常致伴牙周炎迁延不愈的机制研究》,国家自然科学基金面上项目,52万
3.?2025.01.01-2028.12.31:《炎症干扰力诱导的线粒体重排和参与骨改建的作用和机制探究》,国家自然科学基金面上项目,45万
4.?2022.01-2024.12:《巨噬细胞外泌体介导的线粒体代谢功能障碍对间充质干细胞成骨分化功能的影响及其在牙周炎中的作用机制研究》,广东省自然科学基金面上项目,10万
5.?2021.01-2022.12:《基于双向调控成骨-破骨的颁齿颁尝-8/奥苍迟3补双重缓释型3顿打印仿生材料用于牙槽骨再生的产物研发》,广东省科技发展专项资金协同创新与平台环境建设国际科技合作领域项目,50万
6.?2024.01.01-2026.12.31:《智能时空控释工程化间充质干细胞外泌体清除异常线粒体实现牙周缺损再生修复》,广州市科技重点研发计划,50万
7.?2022.01-2022.12:《可注射型超分子水凝胶材料的研发及其在牙周缺损修复治疗中的应用》,高校教师特色创新研究项目,5万
8.?2020.01-2022.12:《牙周炎发生发展的免疫-炎症发病机制及修复重建策略》,17c呱呱爆料一流医院人才建设工程项目杰青培育人才项目,200万
9.?2020.01-2020.12:《可注射型超分子水凝胶牙周缺损修复治疗材料的研发及应用》,中山大学成果转化项目,30万
10.?2020.01-2020.12:《“Seminar”结合“5I Peto”教学法提升口腔医学研究生培养质量的探索与实践》,山大学研究生教育创新计划,5万
【发表论文】
1.?Tong Yan,Huilin Li,Jiayin Yan, Siyuan Ma,Jiali Tan*. Age-related mitophagy regulates orthodontic tooth movement by affecting PDLSCs mitochondrial function and RANKL/OPG. The FASEB Journal. 2024;38:e23865.
2.?Yuyao Liu, Jiayin Yan, Luxian Chen, Yuwei Liao, Lijia Huang, Jiali Tan*. Multifunctionalized and Dual-Crosslinked Hydrogel Promotes Inflammation Resolution and Bone Regeneration via NLRP3 Inhibition in Periodontitis. Small Struct. 2024, 5(3): 2300281
3.?Cheng Hu#,?Mei Zhang#,?Jin Wu#,?Xing Cao,?Luxian Chen,?Jiayin Yan,?Gaolin Liang,?Jiali Tan*.?Bisphosphonate-Modified Functional Supramolecular Hydrogel Promotes Periodontal Bone Regeneration by Osteoclast Inhibition. ACS Applied Materials & Interfaces. 2023;15(7):9066-9079.
4.?Xinwei Lyu#,?Xing Cao#, Luxian Chen, Yuyao Liu?, Huilin Li, Cheng Hu,?Jiali Tan*. Accumulated biomechanical effects of mandibular molar mesialization using clear aligners with auxiliary devices: an iterative finite element analysis. Prog Orthod, 2023, 24(1):13.
5.?Xinwei Lyu, Xing Cao, Jiayin Yan, Runling Zeng, Jiali Tan*. Biomechanical effects of clear aligners with different thicknesses and gingival-margin morphology for appliance design optimization. Am J Orthod Dentofacial Orthop, 2023, 164(2):239-252.
6.?Yajuan Xie, Xinwei Lyu, Yuyao Liu, Runling Zeng, Yuwei Liao, Jiali Tan*. Three-Dimensional Distance Mapping Method to Evaluate Mandibular Symmetry and Morphology of Adults with Unilateral Premolar Scissors Bite. Applied Sciences, 2022, 12(12): 5814.
7.?Yajuan Xie, Runling Zeng, Jiayin Yan, Tong Yan, Jiali Tan*. Introducing surface-to-surface matching technique to evaluate mandibular symmetry: A retrospective study. Heliyon, 2022, 8(7): e09914.
8.?Danfeng Li, Yuyao Liu, Xinwei Lyu, Cheng Hu, Tong Yan, Jiayin Yan, Yuwei Liao, Xiaodan Chen, Jiali Tan*. Small RNA cargo armed extracellular vesicles alleviate periodontitis in OVX mice via M2 macrophage polarization. Chem Eng J. 2022; 435:134870.
9.?Ye Zhang#, Wei Kuang#, Danfeng Li, Yu Li, Yi Feng, Xinwei Lyu, Gao-Bo Huang, Jianqi Lian, Xiao-Fei Yang, Cheng Hu, Yajuan Xie, Song Xue, Jiali Tan*. Natural Killer-Like B Cells-Secreting Interleukin-18 Induces Proinflammatory Response in Periodontitis. Front Immunol. 2021;12:641562.
10.?Xiaodan Chen, Jiali Tan, Yi Feng, Lijia Huang, Mei Zhang, Bin Cheng*. Autophagy in fate determination of mesenchymal stem cells and bone remodeling. World J Stem Cells. 2020,12(8):776-786.
11.?Danfeng Li#, Yi Feng#, Hang Tang, Lijia Huang, Zhongchun Tong, Cheng Hu, Xiaodan Chen, Jiali Tan*. A Simplified and Effective Method for Generation of Experimental Murine Periodontitis Model. Front Bioeng Biotechnol. 2020;8:444.
12.?Yajuan Xie#, Cheng Hu#, Yi Feng, Danfeng Li, Tingting Ai, Yulei Huang, Xiaodan Chen, Lijia Huang, Jiali Tan*. Osteoimmunomodulatory Effects of Biomaterial Modification Strategies on Macrophage Polarization and Bone Regeneration. Regen Biomater. 2020;7(3):233-245.
【社会兼职】
1.?中华口腔医学会正畸专业委员会常务委员
2.?广东省正畸专业委员会常务委员
【联系方式】
地址:广州市越秀区陵园西路56号17c呱呱爆料
邮箱:迟补苍箩颈补濒颈蔼尘补颈濒.蝉测蝉耻.别诲耻.肠苍