【学位 / 学历】
博士 / 研究生
【学术简历】
1985.09-1991.07??华西医科大学口腔医学院口腔医学专业学士学位
1997.09-2000.07??华西医科大学口腔医学院口腔正畸学专业获硕士学位
2000.09-2003.07??四川大学华西口腔医学院口腔正畸学专业博士学位
【研究方向】
1.正畸牙移动相关的基础及临床转化研究
2.生物力学与生物材料相关研究
3.牙周骨改建相关研究
【主持课题】
1.?2021-2024年：《凋亡小体在正畸牙移动骨改建中的作用机制研究》，国家自然科学基金面上项目，55万
2.?2020-2023年：《正畸应力作用下 IL-20 经神经-免疫通信调控破骨细胞活化的机制研究》，国家自然科学基金面上项目，55万
3.?2023.1-2028.12年：《正畸干预联合颁笔础笔与单纯颁笔础笔治疗阻塞性睡眠呼吸障碍的前瞻性随机对照临床研究》，中山大学5010临床研究计划项目，60万
4.?2022-2024年：《正畸牙移动中滨尝-20通过贬滨贵-1α调节巨噬细胞自噬的机制研究》，广东省自然面上项目，10万
5.?2021-2024年：《4顿数字化动态微笑牙移动模型引导的隐形矫治设计 》，中国牙病防治基金，27万
【发表论文】
1.?Ziqi Gan, Zecong Xiao, Zhen Zhang, Yang Li, Chao Liu, Xin Chen, Yuanbo Liu, Dongle Wu, Chufeng Liu, Xintao Shuai, and Yang Cao*.?Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment.?Bioact Mater.?2023;25:347-359. doi: 10.1016/j.bioactmat.2023.01.011. PMID: 36852104; PMCID: PMC9958411. (Q1, IF=18, 最后通讯)
2.?Bowen Meng, Benyi Yang, Yan Qu, Yuanbo Liu, Dongle Wu, Chaoran Fu, Yifan He, Xi Chen, Chufeng Liu, Xiaoxing Kou, and Yang Cao*.?Dual Role of Interleukin-20 in Different Stages of Osteoclast Differentiation and Its Osteoimmune Regulation during Alveolar Bone Remodeling.?Int J Mol Sci.?2023;24(4). doi: 10.3390/ijms24043810. PMID: 36835229; PMCID: PMC9961846. (Q1, IF=4.9, 最后通讯)
3.?Zhengyuan Chen, Liyi Gan, Xin Chen, Jinxuan Zheng, Songtao Shi, Liping Wu, and Yang Cao*.?LncRNA HOTAIRM1 promotes dental follicle stem cell-mediated bone regeneration by regulating HIF-1α/KDM6/EZH2/H3K27me3 axis.?J Cell Physiol.?2023;238(7):1542-57. doi: 10.1002/jcp.31028. PMID: 37120836. (Q1, IF=4.5, 最后通讯)
4.?Lidi Deng, Liping Wu, Dongru Chen and Yang Cao*.?SNHG1 knockdown promotes osteogenic differentiation of hDFSCs through anti-oxidative stress mediated by autophagy.?J Cell Physiol.?2024;239(6):e31283. doi: 10.1002/jcp.31283. PMID: 38651182. (Q1, IF=4.5, 最后通讯)
5.?Bowen Meng, Dongle Wu, Yangfan Cheng, Peina Huang, Yuanbo Liu, Lei Gan, Chufeng Liu, and Yang Cao*.?Interleukin-20 differentially regulates bone mesenchymal stem cell activities in RANKL-induced osteoclastogenesis through the OPG/RANKL/RANK axis and the NF-κB, MAPK and AKT signalling pathways.?Scand J Immunol.?2020;91:e12874?. doi: 10.1111/sji.12874. PMID: 32090353 ?(Q2, IF=4.1, 最后通讯)
6.?Dongle Wu, Xuan Sun, Yiwei Zhao, Yuanbo Liu, Ziqi Gan, Zhen Zhang, Xin Chen, and Yang Cao*.?Strontium Ranelate Inhibits Osteoclastogenesis through NF-κB-Pathway-Dependent Autophagy.?Bioengineering (Basel).?2023;10(3). doi: 10.3390/bioengineering10030365. PMID: 36978756; PMCID: PMC10045081. (Q2, IF=3.8, 最后通讯)
7.?Yuanbo Liu, Yilong Ai, Xuan Sun, Bowen Meng, Xi Chen, Dongle Wu, Lei Gan, Benyi Yang, Chaoran Fu, Yilin Wu, and Yang Cao*.?Interleukin-20 Acts as a Promotor of Osteoclastogenesis and Orthodontic Tooth Movement.?Stem Cells Int.?2021;2021:5539962. doi: 10.1155/2021/5539962. PMID: 34122555 PMCID: PMC8172288 (Q2, IF=3.8, 最后通讯)
8.?Benyi Yang, Chaoran Fu, Yilin Wu, Yuanbo Liu, Zhen Zhang, Xin Chen, Dongle Wu, Ziqi Gan, ngyuan Chen, and Yang Cao*.?γ-Secretase inhibitors suppress IL-20-mediated osteoclastogenesis via Notch signalling and are affected by Notch2 in vitro.?Scand J Immunol.?2022;96(2):e13169. doi: 10.1111/sji.13169. PMID: 35384009. (Q2, IF=4.1, 最后通讯)
9.?Xin Chen, Chao Liu, Rongcheng Yu, Ziqi Gan, Zhen Zhang, Zhengyuan Chen, Yuanbo Liu, Dongle Wu, Xinyi Yu, Chufeng Liu, and Yang Cao*.?Interaction between ferroptosis and TNF-α: Impact in obesity-related osteoporosis.?FASEB J.?2023;37(6):e22947. doi: 10.1096/fj.202201958R. PMID: 37199646. (Q1, IF=4.4, 最后通讯)
10.?Xi Chen, Yuanbo Liu, Bowen Meng, Dongle Wu, Yilin Wu, and Yang Cao*.?Interleukin-20 inhibits the osteogenic differentiation of MC3T3-E1 cells via the GSK3β/β-catenin signalling pathway.?Arch Oral Biol.?2021;125:105111. doi: 10.1016/j.archoralbio.2021.105111. PMID: 33798924 (Q2, IF=2.2, 最后通讯)
11.?Chaoran Fu, Lei Gan, Benyi Yang, Yilin Wu, Bowen Meng, Dongle Wu, Jinxuan Zheng, and Yang Cao*.?Inhibitory effect of infliximab on orthodontic tooth movement in male rats.?Arch Oral Biol.?2022;144:105573. doi: 10.1016/j.archoralbio.2022.105573. PMID: 36341994. (Q2, IF=2.2, 最后通讯)
12.?Yangfan Cheng, Peina Huang, Bowen Meng, Lei Gan, Dongle Wu and Yang Cao*. Antinociceptive effects of the adenylyl cyclase inhibitor ST034307 on tooth-movement-induced nociception in rats. Arch Oral Biol,2019;98: 81–86.PMID: 30465937 (Q2, IF=2.2, 最后通讯)
13.?Dongle Wu, Bowen Meng, Yangfan Cheng, Lei Gan, Peina Huang, and Yang Cao*.?The effect of risedronate on orthodontic tooth movement in ovariectomized rats.?Arch Oral Biol.?2019;105:59-64. doi: 10.1016/j.archoralbio.2019.06.002 PMID: 31276939 (Q2, IF=2.2, 最后通讯)
14.?Peina?Huang?,?Jieyun?Xu,?Lv?Xie?,?Guangqi?Gao,?Shoucheng?Chen,?Zhuohong?Gong,?Xiaomei?Lao,?Zhengjie?Shan,?Jiamin?Shi,?Zhaocai?Zhou,?Zhuofan?Chen, and Yang?Cao*,?Yan?Wang*,?Zetao?Che*.?Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response.?Bioactive Materials.?2023;20:42-52. doi: 10.1016/j.bioactmat.2022.05.013. PMID: 35633873; PMCID: PMC9127122. (Q1, IF=18, 共同通讯)
15.?Guanqi Liu, Xuan Zhou, Linjun Zhang, Yang Zou, Junlong Xue, Ruidi Xia, Nuerbiya Abuduxiku, Xuejing Gan, Runheng Liu, Zhuofan Chen*, Yang Cao*, and Zetao Chen*.?Cell-free immunomodulatory biomaterials mediated in situ periodontal multi-tissue regeneration and their immunopathophysiological processes.?Mater Today Bio.?2022;16:100432. doi: 10.1016/j.mtbio.2022.100432. PMID: 36204216; PMCID: PMC9530615. (Q1, IF=8.7, 共同通讯)
16.?Yang Li, Yi Li, Chao Liu, Xinyi Yu, Ziqi Gan, Lusai Xiang, Jinxuan Zheng, Bowen Meng, Rongcheng Yu, Xin Chen, Xiaoxing Kou*, Yang Cao*, and Tingting Ai*.?Mechanical force-activated CD109 on periodontal ligament stem cells governs osteogenesis and osteoclast to promote alveolar bone remodeling.?Stem Cells Transl Med.?2024;13(8):812-25. doi: 10.1093/stcltm/szae035. PMID: 38885217; PMCID: PMC11328932. (Q1, IF=5.4, 共同通讯)
17.?Haotian Luo, Hio Cheng Ieong, Runze Li, Delan Huang, Danying Chen, Xin Chen, Yuqing Guo, Yangqiao Qing, Bingyan Guo, Ruoyu Li, Yungshan Teng, Wenfeng Li, Yang Cao*, Chen Zhou*, and Weicai Wang*.?Lhx6 deficiency causes human embryonic palatal mesenchymal cell mitophagy dysfunction in cleft palate.?Mol Med.?2024;30:183. doi: 10.1186/s10020-024-00960-2. PMID: 39438838; PMCID: PMC11494960. (Q1, IF=6.0, 共同通讯)
18.?Qingru Niu, Huan Chen, Qianmin Ou, Shuqing Yang, Yingying Peng, Yunyi Xie, Le Yu, Zhilan Cheng, Yang Cao*, and Yan Wang*.?Klotho enhances bone regenerative function of hPDLSCs via modulating immunoregulatory function and cell autophagy.?J Orthop Surg Res.?2023;18(1):400. doi: 10.1186/s13018-023-03849-8. PMID: 37264407; PMCID: PMC10236596. (Q1, IF=2.8, 共同通讯)
19.?Haotian Luo, Danying Chen, Ruoyu Li, Runze Li, Yungshan Teng, Yang Cao*, Xuenong Zou*, Weicai Wang*, and Chen Zhou*.?Genetically engineered CXCR4-modified exosomes for delivery of miR-126 mimics to macrophages alleviate periodontitis.?J Nanobiotechnology.?2023;21(1):116. doi: 10.1186/s12951-023-01863-w. PMID: 36991451; PMCID: PMC10061745. (Q1, IF=10.6, 共同通讯)
20.?Chen Zhou, Danying Chen, Jianhan Ren, Delan Huang, Runze Li, Haotian Luo, Chenyu Guan, Yang Cao*, and Weicai Wang*.?FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex.?J Cell Mol Med.?2021;25(6):3051-62. doi: 10.1111/jcmm.16351. PMID: 33580754; PMCID: PMC7957265. (Q2, IF=4.3, 共同通讯)
21.?R. Li, W. Li, Y. Teng, R. Li, S. Kong, X. Chen, H. Luo, D. Chen, Y. Guo, Y. Qing, H.C. Leong, B. Guo, M. Chen, Z. Pan, S. Zheng, Y. Deng, Y. Cao*, C. Zhou*, X. Zou*, and W. Wang*, Ameliorating macrophage pyroptosis via ANXA1/NLRP3/Caspase-1/GSDMD pathway: ?Ac2-26/OGP-loaded intelligent hydrogel enhances bone healing in diabetic ?periodontitis. Biofabrication 17 (2025). ( IF=8.2, 共同通讯)
22.?C. Zhou, Z. Feng, J. Ren, H. Luo, H.C. Ieong, R. Li, Y. Qing, Y. Guo, B. Guo, Z. Huang, Y. Cao*, and W. Wang*, The effects of clinical crown length on the sagittal movement of maxillary ?central incisor in clear aligner treatment: a finite element exploration. BMC Oral Health 25 (2025) 357. ( IF=2.6, 共同通讯)
23.?G. Liu, R. Xia, M. Gui, L. Zhang, X. Zhou, J. Xue, Y. Cai, Y. Cao*, Y. Xiao*, and Z. Chen*, Turn Hood into Good: Recycling Silicon from Mesoporous Silica Nanoparticles ?through Magnesium Modification to Lower Toxicity and Promote Tissue Regeneration. ACS Nano 18 (2024) 32932-32949. ( IF=15.8, 共同通讯)
【参编教材与论着】
1.??2021年11月 ?参编《无托槽隐形矫治技术拔牙病例精粹》?辽宁科学技术出版社，978-7-5591-2205-6
2.??2020年8月 ?参编《中国青少年隐形矫治专家共识》?四川大学出版社。9787569019629
?
【获奖及学术荣誉】
1.?2021年???广东医院优秀临床科主任
2.?2019年???羊城好医生
【社会兼职】
1.?中华口腔医学会正畸专业委员会副主任委员
2.?广东省口腔医学会正畸专业委员会常务副主任委员
3.?广东省医院协会口腔数字化材料技术管理专业委员会 常务副主任委员
4.?广东省精准医学会咬合颞下颌关节分会常务副主任委员
5.?中国整形协会牙颌颜面医疗美容分会常务理事
6.?广东省口腔医学会医院感染控制与管理委员会常务委员
【联系方式】
地址：广州市陵园西路56号17c呱呱爆料
电话：020-83802804
邮箱：肠补辞测补苍驳蔼尘补颈濒.蝉测蝉耻.别诲耻.肠苍
